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KMID : 0376219960320010025
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Chonnam Medical Journal
1996 Volume.32 No. 1 p.25 ~ p.40
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Ultrastructural Study of Crypt Cells in the Ileum of Mouse after
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Abstract
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The purpose of this study was to clarify the morphologic characteristics of the crypt cells in the small intestine. Electron microscopic studies were performed on the ileum of the mouse at 6 and 20 hours after Salmonella typhimurium infection.
The granule-containing cells of exocrine type in the ileal crypt were composed of four main cell types: Paneth cell, mucous cell, granular mucous cell, and intermediate cell. Among these cells, Paneth cells contained spherical granules, 1~3㎛in
diameter, with centrally located large dense core and narrow electron lucent halo. The granules of the intermediate cells were large spherical, 1~2㎛in diameter, and consisted of dense core and wide halo with halo with moderately dense and
finely
granular matrix materials.
At 6 hours after Salmonella infection, notable changes were observed in the cells of some intestinal crypts. Most of the crypt cell contained granules consisting of electron dense core and wide halo. These granules are resembled those of
intermediate
cells in appearence. Some cells secreted the granules by exocytosis.
At 20 hours after Salmonella infection, the crypt was composed of Paneth cell, intermediate cell, and a cell containing granules of found in Paneth cell and intermediate cell.
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